The in vivo response of human skin to erythemogenic ultraviolet rays was evaluated in six normal and three atopic subjects utilizing a carbon-arc source with therapeutic C carbons and dermal perfusion techniques. Kinin and histamine bioassays of the perfusion fluid revealed no evidence of histamine release. In contrast, kinins appeared within 21 minutes after completion of the exposures in the six normal subjects, Initiation of the perfusions 3 hours and 24 hours after the ultraviolet exposure showed no kinin formation. No kinins were detected in atopic subjects despite development of normal delayed erythema reactions.
Thus, the kinin response was transitory in nature, and was not responsible for the production or persistence of the delayed sunburn erythema.
Epstein JH, Winkelmann RK. Ultraviolet Light-Induced Kinin Formation in Human Skin. Arch Dermatol. 1967;95(5):532–536. doi:10.1001/archderm.1967.01600350094018
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