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June 1967

Skin Tests With Nuclear Factors in Systemic Lupus Erythematosus

Author Affiliations

New Orleans

From the Department of Medicine, Section of Allergy-Dermatology (Drs. Jones and Derbes) and of Arthritis (Dr. Gum), Tulane University School of Medicine, New Orleans, and the Department of Medicine, Section of Rheumatology (Dr. Azoury), Wayne State University College of Medicine, Detroit.

Arch Dermatol. 1967;95(6):559-564. doi:10.1001/archderm.1967.01600360005001

Intradermal testing was carried out on 22 patients with systemic lupus erythematosus (SLE) using homologous leukocytes, nucleoprotein, histone, and deoxyribonucleic acid. Ten patients with positive reactions to DNA had acute lupus and lupus nephritis confirmed by biopsy. Sera from nine of ten of these patients were tested for antinuclear factors (ANF) by the immunofluorescent technique, and the shaggy and homogeneous patterns were exhibited by all.

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