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June 1967

Inability to Induce Keratinization in Basal Cell Tumors: Wounding and Application of Resin Podophyllum

Author Affiliations

New York

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, Md. Dr. Waldorf is presently at the Department of Dermatology, New York University School of Medicine, New York.

Arch Dermatol. 1967;95(6):576-582. doi:10.1001/archderm.1967.01600360022003

Basal cell tumors were superficially wounded or exposed to 24-hour occlusive applications of 0.5% resin podophyllum in alcoholic solution. These stimuli did not induce the tumor cells to participate in the healing process nor to show any detectable sign of keratinization. These observations support the hypothesis that basal cell tumors are derived from cutaneous epithelial cells which have lost the capacity of keratinization.

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