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July 1967

Some in Vitro Effects of Hypoglycin on Skin

Author Affiliations

Birmingham, England

From the Medical Research Council, Unit for Research on the Experimental Pathology of the Skin, the Medical School, University, Birmingham, England.

Arch Dermatol. 1967;96(1):89-93. doi:10.1001/archderm.1967.01610010095017

Some effects of hypoglycin on skin slices maintained in vitro were measured. Hypoglycin inhibited the endogenous respiration of skin slices but had no effect on skin respiration in the presence of added glucose. Ammonia was liberated when hypoglycin was incubated with skin slices. Hypoglycin inhibited the production of [14C] CO from [U-14C] palmitate by skin slices. The significance of these results in relation to theories of the toxicology of hypoglycin is discussed.