Granular cell myoblastoma is an uncommon benign tumor occurring on the skin as a single nodule. Multiple tumors are rare, particularly in children.
This is a case report of a 6-year-old white boy with 12 subcutaneous nodules. The histopathology of the lesions revealed in the dermis islands of large, pale, granular cells. There was histochemical evidence of association of these cells with adjacent nerve bundles.
The histogenesis of this tumor is still disputed, but the most accepted theory today is the neural derivation; the cell of origin is probably the Schwann cell.
The treatment of choice is surgical excision.
Papageorgiou S, Litt JZ, Pomeranz JR. Multiple Granular Cell Myoblastomas in Children. Arch Dermatol. 1967;96(2):168–171. doi:10.1001/archderm.1967.01610020060018
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