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August 1967


Arch Dermatol. 1967;96(2):211-214. doi:10.1001/archderm.1967.01610020103031

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Malignant Melanoma Arising in a Lentigo. Presented by Dr. Wilbur B. Hurlbut.  A 76-year-old white woman noticed an area of increased pigmentation on the right cheek 20 years ago after a trip to Arizona. Ten years ago a tan spot was treated by electrodesiccation, and eight years ago a brownish lesion was excised in the same area. For the past two years, the site has become larger and darker, and for the past four months an enlarging nodule has been present.

Examination.—  On the inner right cheek is a hyperpigmented plaque 33 × 25 mm in size, varying in color from dark brown to black. In the center is a firm nodule with a crusted surface which shows some purulent exudate. No enlarged lymph nodes are felt. A biopsy shows junction activity in the peripheral area, with pigmented cells with large nuclei in the upper cutis and some invading the

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