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September 1967

Erythema Elevatum Diutinum: Presentation of a Case and Evaluation of Laboratory and Immunological Status

Author Affiliations

Los Angeles

From the Department of Medicine, Division of Dermatology, University of California Center for Health Sciences, Los Angeles. Dr. Mraz is now at 635 Anderson Rd, Davis, Calif 95616.

Arch Dermatol. 1967;96(3):235-246. doi:10.1001/archderm.1967.01610030013003

Erythema elevatum diutinum (EED) is a chronic cutaneous disease characterized by nodules and plaques in an acral and symmetrical location. Histologically, the earliest findings are a vasculitis in the dermis associated with an inflammatory-cell infiltrate and a tinctorial change in the vessel wall and adjacent perivascular fibers. The histologic findings are thought to be highly characteristic. Extracellular cholesterosis (EC) most likely represents a variant in which lipids are secondarily deposited between the collagen bundles. The earlier division of EED into the Hutchinson and Bury types is no longer thought to be warranted.

A patient is presented with clinical and histological features of EED; an elevation of several amino acids in the urine with essentially normal plasma levels was revealed.

Elevations of IgG and IgA, and a mild elevation in leukocyte alkaline phosphatase were present.

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