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September 1967

Adrenocortical Suppression With Topical Flumethasone

Author Affiliations

Columbus, Ohio

From the divisions of dermatology (Dr. Carr) and endocrinology (Dr. Wieland), Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio.

Arch Dermatol. 1967;96(3):269-272. doi:10.1001/archderm.1967.01610030047007

Flumethasone pivalate cream, 0.03%, inuncted to the entire integument under polyethylene film wraps resulted in sufficient percutaneous corticosteroid absorption to cause adrenocortical suppression in three patients with severe, generalized, exfoliative dermatitis. Despite several recent reports indicating that this topical corticosteroid does not suppress adrenocortical function, it appears that this new, fluorinated steriod can cause such suppression if applied in sufficient amounts under occlusive dressings in patients with extensive and severe dermatoses.

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