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October 1967

Methotrexate in Psoriasis: Precipitation of Gout

Author Affiliations


From the departments of rheumatology (Dr. Martin and Mr. Wallace) and dermatology (Dr. Gordon), Temple University Health Sciences Center, Philadelphia.

Arch Dermatol. 1967;96(4):431-433. doi:10.1001/archderm.1967.01610040081015

Two psoriatic patients are reported with hyperuricemia and gout who had an episode of acute gouty arthritis within 24 hours after the administration of methotrexate intravenously.

A patient with gout and psoriasis, in which treatment with methotrexate is contemplated should probably receive prophylactic colchicine to prevent the precipitation of gouty attacks.