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November 1967

Methotrexate: Effects on the Enzymes of Carbohydrate Metabolism in Psoriasis

Author Affiliations

Portland, Ore

From the Department of Dermatology, University of Oregon Medical School, Portland, Ore.

Arch Dermatol. 1967;96(5):565-571. doi:10.1001/archderm.1967.01610050087015

Methotrexate administration to patients with psoriasis results in clinical improvement over a period of weeks unaccompanied by any observable change in the uninvolved skin. Biochemically, enzyme activities are decreased in both the involved and noninvolved skin. The decreases in the involved areas correlate fairly well with the observed clinical improvement. The specific relative pattern of the increased enzyme activities characteristic of the psoriatic lesion is lost when enzyme activities are depressed by the action of methotrexate.