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To the Editor.—
Dr. E. Epstein's account of the use of mixtures in patch testing in the March 1967 issue of the Archives is very interesting. We in the London Hospital have been using mixtures since 1956. The original idea was to use the mixtures to test people with eczema on a more or less blind basis to see if any useful information could be obtained, and to use the tests on people who were not good at giving histories. The tests did not fulfill these particular functions well, but have been useful as screening tests in those with obvious contact eczema where there was reason to suspect contact with the ingredients.The first mixtures were the metal and antibiotic cocktails. The metal cocktail contains nickel sulfate, cobalt chloride, copper sulfate, and potassium dichromate 1% in water. Patients reacting to it were tested to the ingredients. The results have been
Pegum JS. COMMENTS ON EPSTEIN'S USE OF MIXTURES IN PATCH TESTING. Arch Dermatol. 1967;96(6):741. doi:10.1001/archderm.1967.01610060135029
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