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December 1967


Arch Dermatol. 1967;96(6):741. doi:10.1001/archderm.1967.01610060135030

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To the Editor.—  In the report "Nevus Unius Lateralis, Brain Tumor, and Diencephalic Syndrome," which appeared in the May issue of the Archives (95:501, 1967), Capt Meyerson stresses the association of a neurological disorder with a dermatological condition. He does not, however, discuss the association of a unilateral epidermal nevus with a tumor. Such an association was also present in this patient and was previously reported by Pack and Sunderland (Arch Surg43:341, 1941) and myself (Postgrad Med41:447, 1967). Pack and Sunderland saw unilateral epidermal nevi associated with a mammary adenocarcinoma, and epidermoid esophageal cancer, and an epidermoid cancer of uncertain origin in three patients, respectively. It is possible that in one instance the authors were dealing with unilateral malignant acanthosis nigricans. I observed a patient who had benign symmetric acanthosis nigricans at puberty, a unilateral epidermal nevus indistinguishable from acanthosis nigricans since birth, and a

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