Fourteen percent of hamsters inoculated intracutaneously with Paracoccidioides brasiliensis developed nonulcerating nodules in the skin with regional lymphadenitis and occasionally with dissemination. Intraperitoneal or intratesticular injections produced blastomycotic lesions in the abdominal organs more frequently and even pulmonary foci developed occasionally.
The low rate of skin lesions suggests that cutaneous infection is not a favorable site for spontaneous primary inoculation. Contrary to the results with other dimorphic fungi, disease of internal organs could be confirmed more often by histologic examination than by culture.
Salfelder K, Schwarz J, Johnson CE. Experimental Cutaneous South American Blastomycosis in Hamsters. Arch Dermatol. 1968;97(1):69–77. doi:10.1001/archderm.1968.01610070075011
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