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January 1968

Experimental Cutaneous South American Blastomycosis in Hamsters

Author Affiliations


From the Department of Pathology, Universidad de los Andes, Merida, Venezuela (Dr. Salfelder), the Laboratory of Mycology (departments of dermatology and pathology), University of Cincinnati College of Medicine, and the Clinical Laboratories (Dr. Schwarz) and Department of Bacteriology (Dr. Johnson), Jewish Hospital, Cincinnati.

Arch Dermatol. 1968;97(1):69-77. doi:10.1001/archderm.1968.01610070075011

Fourteen percent of hamsters inoculated intracutaneously with Paracoccidioides brasiliensis developed nonulcerating nodules in the skin with regional lymphadenitis and occasionally with dissemination. Intraperitoneal or intratesticular injections produced blastomycotic lesions in the abdominal organs more frequently and even pulmonary foci developed occasionally.

The low rate of skin lesions suggests that cutaneous infection is not a favorable site for spontaneous primary inoculation. Contrary to the results with other dimorphic fungi, disease of internal organs could be confirmed more often by histologic examination than by culture.

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