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March 1968


Arch Dermatol. 1968;97(3):362-364. doi:10.1001/archderm.1968.01610090134030

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Melanoderma of Unknown Etiology. Presented by Dr. Lewis Shapiro. 

History.—A  7-year-old girl, was first seen 4 weeks ago because of an asymptomatic rash of two years' duration. According to the patient's mother new lesions have continued to appear, the initial ones have not resolved, but the rash varies in intensity at times. The individual lesions are brown spots, but at one time there was thought to be some associated erythema, when they first appeared. The patient's mother denies, however, that any redness has been associated with the development of the more recent lesions. It was thought that the erythema was possibly associated with a combination of aspirin, aluminum glycinate, and magnesium carbonate (Bufferin) and tetracycline (Achromycin). The patient was challenged with both of these medications, each being given b.i.d. separately for two days (four doses of each) without any change in the rash.

Past History.—  Her general health has been

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