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June 1968

Solid-Cystic Hidradenoma of the Skin: Clinical and Histopathologic Study

Author Affiliations

Rochester, Minn

From the Mayo Clinic and Mayo Foundation: Section of Dermatology (Dr. Winkelmann) and the Mayo Graduate School of Medicine (University of Minnesota) (Dr. Wolff), Rochester, Minn.

Arch Dermatol. 1968;97(6):651-661. doi:10.1001/archderm.1968.01610120041005

Clinical and microscopic data on 41 solidcystic hidradenomas are presented. These tumors occur more frequently in females than in males and may be found in all regions of the body and in patients of any age although there is a predilection for the middle and older age groups. The lesions are solitary and represent cutaneous and subcutaneous nodular and cystic masses of slow, expansile growth. Histologically they are solid and cystic and are composed of epidermoid cells which may undergo transformation into clear cells. The tumors contain glycogen, but acid mucopolysaccharides are found only occasionally and only in minute amounts. None of the 41 tumors showed signs of malignancy. Our findings indicate that solid-cystic hidradenoma of the skin represents a clinically and microscopically distinct sweat gland neoplasm which should be separated from other types of hidradenomas and appendageal tumors.

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