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June 1968

The Role of Immunologic Aberrations in the Pathogenesis of Lymphoma: With Particular Reference to Mycosis Fungoides and Exfoliative Erythroderma

Author Affiliations

Los Angeles

From the Department of Medicine, Division of Dermatology, University of California, Los Angeles Medical Center and the divisions of dermatology, Wadsworth General and Long Beach Veterans hospitals.

Arch Dermatol. 1968;97(6):699-711. doi:10.1001/archderm.1968.01610120089014

AUNITARIAN theory of the pathogenesis of malignant lymphoma seems improbable considering the multiplicity of morphologic types, histopathologic distinctions and variable clinical courses suggesting that there are multiple etiologic determinants of lymphoid malignancies. The induction of lymphoma in mice by oncogenic viruses1-4 and chemical carcinogens,5-8 epidemiologic9 and hereditary influences10-12 in Hodgkin's disease, the development of lymphomas as a consequence of the administration of anticonvulsant drugs13 and exposure to x-radiation,14,15 and studies of Burkitt's lymphoma16 all bespeak a great diversity of inductive influences. During the past decade persuasive insight into the pathogenesis of lymphoid malignancies has been advanced by the revelation that immunologic aberrations predispose to, are inductive, or are important associated features of malignant lymphoproliferative disease. The purpose of this paper is to review the experimental studies and clinical research relevant to the determinant role of abnormalities of immune mechanisms in the pathogenesis