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Volume 11 of Progress in Allergy, contains four excellent and comprehensive reviews on important and currently active fields of immunological investigation. The reviews are themselves well abstracted in Dr. Kallos' introduction. In "Mediators of the Arthus and Related Reactions" C. G. Cochrane discusses present knowledge of the events that take place in tissues following the interaction of relatively large amounts of antibody with antigen, with the activation of complement, wherein granulocytes accumulate and, probably by liberating various mediators, eventuate in tissue damage. The Arthus reaction, acute glomerulitis of nephrotoxic nephritis and the arteritis of serum sickness are each examined as examples of this mechanism and the various components of complement and vasoactive proteins that act as mediator substances are described.
In "Granulomatous Hypersensitivity," W. L. Epstein deals with the immunopathology of granuloma formation and concentrates on the epithelial cell as the unique cell in this hypersensitivity response. In a review
Caron GA. Progress in Allergy: Vol 11. Arch Dermatol. 1968;97(6):739–740. doi:10.1001/archderm.1968.01610120129022
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