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July 1968

Pathogenesis of Acne Vulgaris: I. Comedogenic Properties of Human Sebum in External Ear Canal of the Rabbit

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1968;98(1):53-57. doi:10.1001/archderm.1968.01610130059013

Scalp sebums of 64 young men were applied once daily for ten times to the external ear canal of the rabbit. In every instance follicular hyperkeratosis resulted.

This finding supports the conception that sebum contains substances that directly stimulates the follicle to form a comedo, the elementary lesion in acne vulgaris.