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July 1968

Pathogenesis of Acne Vulgaris: II. Histopathology of Comedones Induced in the Rabbit Ear by Human Sebum

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1968;98(1):58-66. doi:10.1001/archderm.1968.01610130064014

The daily application of human sebum for two weeks to the external canal of the rabbit ear induced the following histologic changes: (1) hyperplasia of the epidermis and epithelial linings of the sebaceous ducts and follicles, (2) distention of the ducts and follicles with keratinized squamae to form horny impactions or comedones, and (3) variable inflammatory changes exemplified by follicular pustules and infiltration of the dermis by mononuclears and polymorphonuclear leukocytes.

The comedogenic potency of sebum is considerably less than that of a chemical acneigen such as Halowax 1014. The comedones were smaller and never attained maturity.

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