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July 1968

Enzymatic Characteristics of Human Basal Cell Epithelioma

Author Affiliations

Portland, Ore

From the Division of Dermatology, Department of Medicine, University of Oregon Medical School, Portland.

Arch Dermatol. 1968;98(1):80-84. doi:10.1001/archderm.1968.01610130086017

When compared with normal epidermis, basal cell epitheliomas show increased activities of 6-phosphogluconate dehydrogenase, isocitric dehydrogenase, and phosphofructokinase. The activities of hexokinase, aldolase, pyruvic kinase, lactic dehydrogenase, and malic dehydrogenase are decreased in basal cell epithelioma as compared with normal epidermis. These latter findings are in contrast to prior studies with psoriatic epidermis in which the activities of all enzymes except phosphorylase were increased.

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