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August 1968

Regional Differences in Parakeratotic Response to Mild Zinc Deficiency

Author Affiliations


From the Department of Oral Pathology, University of Illinois at the Medical Center, Chicago.

Arch Dermatol. 1968;98(2):191-201. doi:10.1001/archderm.1968.01610140089022

Orthokeratinized epithelia of the rat showed regionally differing reproducible responses to a diet containing 1.7 ppm of zinc. Responses ranged from 100% conversion to parakeratinization in buccal mucosa and less complete conversion in other regions to total absence of experimental changes in palatal mucosa.

Susceptible regions showed persistence of pericellular glycoproteins, of cytoplasmic basophilia and nucleolar prominence in upper cellular layers, in addition to retention of nuclei in the keratin layer. Furthermore, thickening of keratin and cellular layers was followed by a progressively increased rate of cell division.

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