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September 1968

Isoenzymes of the Human Epidermis

Author Affiliations

Portland, Ore

From the Department of Medicine, Division of Dermatology, University of Oregon Medical School, Portland, Oregon. Drs. Halprin and Fukui are now at the Veterans Administration Hospital, Miami, Fla, and Dr. Ohkawara is now at the University of Hakkaido, Hakkaido, Sapporo, Japan.

Arch Dermatol. 1968;98(3):299-309. doi:10.1001/archderm.1968.01610150085016

Further studies designed to clarify the isoenzymic forms of glycolytic enzymes within the human epidermis have revealed one protein (enzyme) with hexokinase activity, three with phosphoglucomutase activity, one with phosphohexose isomerase activity, five with aldolase activity, one with phosphoglycerate mutase activity, two with enolase activity, one with pyruvate kinase activity, and two with phosphorylase activity. The single form of hexokinase corresponds to type I of liver which is not insulin sensitive. The single form of pyruvate kinase corresponds to type III of liver which is not inducible by insulin. Both phosphorylase a and b which probably correspond to muscle type phosphorylase rather than liver are present in epidermis. In addition, a phosphorylase kinase capable of converting b to a can be demonstrated.

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