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December 1968


Arch Dermatol. 1968;98(6):682. doi:10.1001/archderm.1968.01610180126026

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To the Editor.—  I would appreciate it if you could publish the following correction to my discussion of a patient with alopecia and ichthyosis while on "Zyloprim" brand allopurinol, which appeared in the July 1968 issue of the Archives, p 104.Xanthine oxidase is involved in the metabolism of purines, is probably not essential to cellular metabolism, and is not a cytotoxic agent.Allopurinol is synergistic only with mercaptopurine and azathioprine. The company and the literature suggest that the dose of these drugs be markedly lowered, usually by 75%, that is to 25% of their usual dose, when used together with allopurinol. This combination should be used only by people experienced in the field.

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