A case of lues maligna, an unusual form of secondary syphilis is presented. The primary clinical features of the disease were ulcerating skin lesions with rupioid crusting, and a strongly reactive VDRL. Biopsy showed an obliterative vasculitis. Oral tetracycline effected rapid resolution of the lesions. The hypothesis is presented that the disease represents a progressive form of papulopustular secondary syphilis. Poor nutrition and generalized debility is a feature of many of the cases and may be of etiological significance.
David A. Fisher, Lennig W. Chang, Denny L. Tuffanelli. Lues MalignaPresentation of a Case and a Review of the Literature. Arch Dermatol. 1969;99(1):70–73. doi:10.1001/archderm.1969.01610190076014