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February 1969


Arch Dermatol. 1969;99(2):237-240. doi:10.1001/archderm.1969.01610200109018

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Arsenical Keratoses and Internal Cancer (Urinary Bladder and Nasopharynx). Presented by Sam C. Atkinson, MD.  A 45-year-old white woman has developed progressively enlarging keratoses on the trunk and extremities for the past several years. During adolescence she took arsenic drops (Fowler's solution) for two years for acne. (Her physician was not a dermatologist.) She has lived in the tropics much of her life and admits to excessive sun exposure. Cancer of the nasopharynx was treated surgically at Memorial Hospital, New York city, in 1964. Dissection of the cervical nodes was done at the time. Cancer of the urinary bladder was treated by radiation and surgery in October 1967.

Examination.—  Innumerable crusted elevated and inflamed keratoses are scattered over the face, body, and, to a lesser extent, the extremities. When the crust is removed the surface bleeds easily. Typical punctate keratoses are present on the palms and soles.A biopsy disclosed

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