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March 1969


Arch Dermatol. 1969;99(3):375-378. doi:10.1001/archderm.1969.01610210129027

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Lymphosarcoma of Lymph Nodes. Acute Eruption, Undetermined Cause. Presented by William B. Reed, MD.  In October 1967, this 66-year-old woman noted a mass in the left cervical lymph node chain. In January 1968, a resection of the nodes revealed a lymphocytic lymphosarcoma. She was given 10 cobalt radiation treatments, and in the area of the radiation an eczematous eruption developed. After nupercaine (Nupercainal) ointment was applied, a generalized urticarial and purpuric eruption followed. The eruption has not responded to corticotropin (Acthar) gel injections. The color of the lesions suggests generalized lymphosarcoma of the skin. A brother died of Hodgkin's disease.

Discussion  Paul Hirsch, MD: The lymph node biopsy shows features of a malignant lymphoma. The normal architecture is absent and the infiltrating cells are atypical, monomorphous, and fairly uniform in appearance. I therefore would classify this lesion as a well-differentiated lymphocytic lymphoma or lymphosarcoma. In view of the patient's altered

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