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June 1969

Hyperkeratosis Lenticularis Perstans: A Clinical, Histopathologic, and Genetic Study

Author Affiliations


From the University of Minnesota Hospitals, Department of Medicine, Division of Dermatology, Minneapolis.

Arch Dermatol. 1969;99(6):705-709. doi:10.1001/archderm.1969.01610240063011

The clinical, histologic, and genetic characteristics of four patients with hyperkeratosis lenticularis perstans are reported. The clinical lesions are multiple pink to reddish-brown, scaly papules occurring most frequently over the dorsa of the feet, legs, hands, and arms. The histologic findings include hyperkeratosis and parakeratosis, an atrophic or acanthotic epidermis, and a bandlike or perivascular round cell infiltrate. Three of the patients studied were from the same family and represent the first related cases to be reported. This familial incidence suggests that hyperkeratosis lenticularis perstans is a genodermatosis with an autosomal dominant mode of transmission. The title of benign familial acrokeratoses is proposed.

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