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June 1969


Arch Dermatol. 1969;99(6):770-778. doi:10.1001/archderm.1969.01610240128023

Erythropoietic Coproporphyria and Protoporphyria. Presented by Mark Gordon, MD, and William Stern, MD.  A 39-year-old white man has had a history of sun sensitivity since age 3. Sun exposure for one hour from late spring to early autumn produces burning and pruritus, followed by erythema and induration on the exposed areas. Vesicular or eczematous eruptions have never occurred. Occasionally, skin lesions follow prolonged exposure to bright sunlight in the winter if there is snow on the ground.One year ago, he had a cholecystectomy for cholelithiasis. An analysis of the stones for porphyrins was not done.

Dermatological Examination.—  There was moderate erythema and thickening of the skin over the dorsal metacarpal-phalangeal and interphalangeal areas, as well as erythema over the dorsal aspects of both hands (Fig 1).

Laboratory Studies.—  The following studies were normal or negative: hemogram, urinalysis, lupus erythematosus (LE) preparation, liver function studies, serum iron, iron binding capacity,

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