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The first recorded use of cryosurgery for cancer was in 1845 by James Arnott. However, it was not until 1895 that Linde successfully produced large quantities of both liquid nitrogen and liquid air. Dermatologists, using the cotton swab, soon recognized the usefulness of this form of therapy. This book is an extensive discussion of the use of cold in medicine and includes, in addition to a history, chapters on its use in such disciplines as ophthalmology, otolaryngology, gynecology, and urology. There is only a short chapter devoted to cryosurgery of malignant lesions of the skin by Setrag A. Zacarian but he describes the advantages of a copper disc for application of liquid nitrogen. However, the shortcoming from the dermatologist's standpoint is that there is no discussion of its usefulness for the many other lesions commonly treated by the dermatologist. Also, there is no discussion of the effective carbon dioxide "stick"
Sams WM. Cryosurgery. Arch Dermatol. 1969;99(6):784. doi:10.1001/archderm.1969.01610240142025
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