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July 1969


Author Affiliations

Government Municipal Medical Center Hadassah Hospital Tel-Aviv, Israel

Arch Dermatol. 1969;100(1):117. doi:10.1001/archderm.1969.01610250123031

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To the Editor.—  The use of immunosuppressive drugs in pemphigus vulgaris has not, as far as we know, been published.We would like to report a case treated by a combination of steroids and azathioprine (Imuran) and, subsequently, by azathioprine only.

Report of a Case.—  A 66-year-old woman was hospitalized one year earlier because of extensive ulcerations of the mouth and scattered lesions on the head, shoulders, chest, and upper back. The blood pressure was 130/80. Biopsy from a skin lesion confirmed the diagnosis of pemphigus vulgaris.Prednisone therapy began with 100 mg daily. The mouth ulcerations healed; the skin lesions proved more resistant and by the end of three months cleared only partially. Attempts to lower the maintenance dose of prednisone to less than 30 mg a day failed.After several weeks' treatment the skin manifestations deteriorated. Because of the continued appearance of new lesions, increasing amounts of prednisone

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