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August 1969

Cat-Scratch Disease: Histopathologic Changes in the Skin

Author Affiliations

USN; Washington, DC

From the Skin and Gastrointestinal Pathology Branch, Armed Forces Institute of Pathology, Washington, DC.

Arch Dermatol. 1969;100(2):148-154. doi:10.1001/archderm.1969.01610260024004

Biopsies of skin lesions in cat-scratch disease have received relatively little attention. This report describes the histologic changes in four primary skin lesions, one conjunctival lesion, and one intradermal skin test.

The consistent changes observed were a central acellular zone of necrosis surrounded by histiocytes, giant cells, and a mantle of lymphocytes.

These findings are equivalent to changes reported in lymph nodes from cat-scratch disease, and biopsy of skin lesions is a recommended step to be included with other diagnostic studies for cat-scratch disease.