Detailed histologic analysis of the stages of localized calciphylaxis in rat skin suggests that the calcified carapace does not contain the complete skin and that sufficient connective tissue and epithelium remains behind to serve as a source of regeneration. The regenerate is incomplete and has many features of scar tissue. Elastic fibers are not restored. The number of hairs is greatly diminished. It could not be ascertained whether all of the hairs growing later come from surviving hair roots, or if true neogenesis plays a part.
Other details of interest are the greatly increased amount of calcium in growing hairs and the absence of alcian blue stainable substances in mast cell granules following calciphylaxis.
Kelly EW, Milkintas J. Skin and Hair Regeneration After CalciphylaxisHistologic Changes During Formation and Shedding of the Calciphylactic Carapace of the Rat. Arch Dermatol. 1969;100(2):230–233. doi:10.1001/archderm.1969.01610260106020
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