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August 1969


Author Affiliations

Communicable Disease Center Atlanta 30333

Arch Dermatol. 1969;100(2):260. doi:10.1001/archderm.1969.01610260136029

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To the Editor.—  Dr. Robinson's review article on "Congenital Syphilis" (Arch Derm99:599-610 [May] 1969) is certainly very timely in that it allows me to relate to you that the Venereal Disease Branch of the National Communicable Disease Center, with the assistance of the Venereal Disease Research Laboratory, is presently evaluating what we believe to be a specific test for early congenital syphilis. This test is a modification of the FTA-ABS. Specifically, it employs monospecific anti-human IgM which has been tagged with fluorescein. The advantage of this test is that it is not influenced by passive transfer of immunoglobulins from mother to fetus and, therefore, we feel it identifies only immunoglobulin produced by the fetus.At the present time we have evaluated approximately 150 such tests. Our preliminary data correlate well with the physical and historical information that accompanies these cases. Inasmuch as this test is in its early

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