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October 1969

Osteopoikilosis Associated With Dermatofibrosis Lenticularis Disseminata

Author Affiliations


From the departments of dermatology and pathology, University of Copenhagen, Copenhagen.

Arch Dermatol. 1969;100(4):465-470. doi:10.1001/archderm.1969.01610280083016

We report a patient with osteopoikilosis and dermatofibrosis lenticularis disseminata with unusual flexural location. The patient was undersized, had diabetes mellitus, and pronounced arteriosclerotic changes. Histologic examination showed the cutaneous lesions sharply demarcated with a pseudotumorous appearance. Electron microscopic studies of these lesions revealed some of the elastic fibers broken up, partly into big lumps consisting of the amorphous component, partly into smaller granular elements, presumably representing the fibrillar component. The collagen fibers were normal. A certain resemblance to pseudoxanthoma elasticum is discussed.