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October 1969


Author Affiliations

Therapeutics Research Division Miles Laboratories, Inc. Elkhart, Ind 46514

Arch Dermatol. 1969;100(4):489. doi:10.1001/archderm.1969.01610280107025

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To the Editor.—  For the past several years we have been involved in a program requiring measurements of intraocular pressure (IOP) in rabbits, dogs, and cats. In the course of this time, involving 100 to 200 IOP measurements daily, using proparacaine as the topical anesthetic, we have observed local contact dermatitis manifested by dryness and fissuring of the fingertips. This phenomena was limited to the thumb and forefinger of each hand which were used to hold the eye open during applanometry. This dermatitis was severe for myself resulting in bleeding fissures and continuous peeling and scaling of the epidermis. Less severe scaling and peeling was observed in two technicians.Until last fall I thought possibly that an allergy had developed to rabbit fur. Subsequent patch testing with rabbit dander was negative. Patch testing with benzalkonium chloride, chorbutanol, and methylcellulose which was contained in various ophthalmic vehicles, were also negative. Patch

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