[Skip to Navigation]
November 1969

Metabolic Alkalinization in Porphyria Cutanea Tarda

Author Affiliations

Rochester, Minn

From the Mayo Graduate School of Medicine (University of Minnesota), Rochester (Dr. Wiegand) and the Mayo Clinic and Mayo Foundation (Dr. Perry). Dr. Copeman was the recipient of a Wellcome Research Travel Grant at the time of the study and is Consultant Physician for Diseases of the Skin, Westminster Hospital, London.

Arch Dermatol. 1969;100(5):544-549. doi:10.1001/archderm.1969.01610290028006

At the Mayo Clinic, four patients with porphyria cutanea tarda were treated with metabolic alkalinization by orally administered sodium bicarbonate for ten weeks to nine months. Clinically, blistering and ulceration that had occurred after sun exposure and trauma were reduced or completely alleviated. Under the experimental conditions outlined, the skin in the light-exposed areas in two of the patients became more resistant to controlled blistering by a suction apparatus. These observations of clinical activity and porphyrin excretion indicate that systemic alkalinization may be beneficial in the treatment of porphyria cutanea tarda.

Add or change institution