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November 1969

Histologic Effect of Fluorouracil on Normal Skin

Author Affiliations

Pasadena, Calif

From the Department of Medicine, Section of Dermatology, School of Medicine, University of Southern California, Los Angeles.

Arch Dermatol. 1969;100(5):608-609. doi:10.1001/archderm.1969.01610290092021

In a controlled clinical trial, 12 white men with normal skin applied 1% fluorouracil in propylene glycol to the medial aspect of the left upper arm twice daily for 14 days. At the end of the treatment period, a 4-mm punch biopsy was taken from the center of the treated area. A similar 4-mm biopsy was taken from the opposite untreated arm. Biopsy specimens were randomly coded "A" and "B" in a double-blind fashion, and stored in buffered Formalin until evaluated. This study confirms previous conclusions that 1% fluorouracil does not affect nonkeratotic skin.