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November 1969

Recent Advances in Androgen Metabolism and Their Relation to the Skin

Author Affiliations


From the Department of Dermatology and Evans Memorial Department of Clinical Research, University Hospital, and the Department of Dermatology, Boston University School of Medicine, Boston University Medical Center, Boston.

Arch Dermatol. 1969;100(5):621-636. doi:10.1001/archderm.1969.01610290105024

FOR many years the standard laboratory examination for assessing androgenicity was the urinary excretion of 17-ketosteroids. Cumulative experience, however, made it quite clear that a correlation between the two was not always possible. In recent years, as a result of the availability of both better instrumentation and labeled isotopes, techniques have been developed for the determination of specific androgens such as testosterone in blood and urine. As a result, vigorous renewed interest has been generated in the field of androgen metabolism. The purpose of this review is to discuss some of the new information that has come from these studies and, in particular, those bearing actual or potential relevance to the skin.

Pathways of Steroid Synthesis and Metabolism  A brief review of steroid synthesis and metabolism is desirable at this point for a better understanding of the subsequent material. A simplified scheme for the biosynthesis of hormonal steroids is

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