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January 1970

Allergic Contact Dermatitis to Epinephrine

Author Affiliations

New York

From the Department of Dermatology, New York University School of Medicine, New York.

Arch Dermatol. 1970;101(1):92-94. doi:10.1001/archderm.1970.04000010094017

A patient is described who was shown to be allergic by closed patch testing to epinephrine-(L -epinephrine) which was contained in an ophthalmic preparation. The several other ingredients in the fluid vehicle were negative. Repeat patch testing a few months later was again positive for epinephrine, but negative for its stereoisomer D-epinephrine. Still later, further testing to epinephrine, including scratch testing, proved negative. A final episode of clinical contact dermatitis apparently caused by reexposure to the offending ophthalmic preparation was associated with negative patch-test results to epinephrine and the eye drops.

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