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January 1970


Author Affiliations

19 North Terrace St. Peters South Australia, 5069

Arch Dermatol. 1970;101(1):115. doi:10.1001/archderm.1970.04000010117025

To the Editor.—  Willis and Kligman1 in a recent paper maintain that persistent light reactions, whether generalized or localized, from halogenated salicylanilides and their related compounds, follow the retention of these bacteriostatic agents in the skin over long periods. My experience of "localized persistent light reaction" would lead me to believe that this is a completely logical explanation, and I wonder whether their findings might have wide implications.Many syndromes involving the skin induced by drugs, food additives, and environmental contaminants have been reported.2 Cases have been reported where the classical appearances of systemic lupus erythematosus vanished once the drug cause or trigger was removed.3 Should, however, causative drugs be attached to skin for long periods as suggested by Willis and Kligman's findings, this might supply a complete explanation for the syndrome of systemic lupus erythematosus. Food additives might be entirely unsuspected causes.Many cases of exfoliative

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