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April 1970


Author Affiliations

Dermatology Suite 26 812 Cook Rd Richmond, BC

Arch Dermatol. 1970;101(4):486-487. doi:10.1001/archderm.1970.04000040108027

To the Editor.—  I have read with interest the case report on the surgical treatment of familial benign pemphigus.1 The authors are to be congratulated on presenting an undoubted advance in the surgical treatment of this condition. However, there are certain statements which raise points of discussion. One such is, "Apparently, the original axillary skin had an intrinsic genetic predisposition to this form of pemphigus." While this statement is true, I believe the authors imply that genetic predisposition is confined to the axillae and other commonly affected sites. In contrast, our paper in the Archives in September 1967,2 suggested that acantholysis could be induced in many different sites when a warm, moist environment was provided with, in addition, a stimulus such as Candida albicans. In the case under discussion, could the cure of the local disease not be due to the alteration of the local environment, namely, to