An attempt to use leucovorin calcium "rescue" in ten patients with severe psoriasis who had been successfully treated with methotrexate resulted in failure due to increased psoriatic activity.
Cipriano AP, Selsky LM, Bertino JR. Failure of Leucovorin "Rescue" in Methotrexate Treatment of Psoriasis. Arch Dermatol. 1970;101(6):651–652. doi:10.1001/archderm.1970.04000060023005
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