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July 1970

Systemic Amyloidosis Complicating Dermatoses

Author Affiliations

Washington, DC

From the Dermal Pathology Branch, Armed Forces Institute of Pathology, Washington, DC. This work was done during Dr. Brownstein's tenure at AFIP as an Earl B. Osborne Fellow in Dermal Pathology of the American Academy of Dermatology.

Arch Dermatol. 1970;102(1):1-7. doi:10.1001/archderm.1970.04000070003001

Certain dermatoses may be complicated by systemic amyloidosis. The underlying disorders in eight of 100 patients with secondary systemic amyloidosis studied at autopsy were: hidradenitis suppurativa, stasis ulcers, psoriatic arthritis, basal cell carcinoma, dystrophic epidermolysis bullosa, and lepromatous leprosy (three cases). When proteinuria or hepatomegaly is discovered in a patient with a potentially amyloidogenic dermatosis, the possibility that secondary systemic amyloidosis has developed should be considered.

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