FIXED-DRUG ERUPTION DUE TO TETRACYCLINE

To the Editor.—  In the Case Report "Fixed Drug Eruption Due to Tetracycline" Minkin et al (Arch Derm100:749, 1969) state that their patient is the second reported case of fixed-drug eruption due to tetracycline.They cited the case reported by Welsh¹ but overlooked two others^2,3 reported in the Archives. I have recently reported another patient.⁴Their discussion also omitted mention of Ninomiya's⁵ report of fixed-drug eruption due to oxytetracycline.That it is probably the parent tetracycline compound which is actually responsible for producing the eruption is indicated by Welsh's^1,6,7 series of papers and Dougherty's⁸ in which single patients were shown to cross-react to chlortetracycline, oxytetracycline, and tetracycline.