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September 1970


Arch Dermatol. 1970;102(3):352. doi:10.1001/archderm.1970.04000090114023

To the Editor.—  In studying the levels of any substance in the skin, it is essential not to lose sight of three independent factors: (1) the concentration of this substance in the epidermis; (2) its concentration in the dermis; and (3) the ratio between the weights of epidermis and dermis in the analyzed material. Any of these factors can influence the analytical data as expressed per unit weight of whole skin.In their article "Zinc Therapy and Distribution in Psoriasis" (Arch Derm 100:669-673, 1969) Voorhees et al reported consistently higher zinc levels in psoriatic lesions than in uninvolved skin in a group of four patients. They stated that this increase would have to be demonstrated in more cases in order to reach statistical significance.In an investigation of trace element levels in psoriasis, using neutron activation analysis, we found a significant increase in epidermal zinc levels in both involved and

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