A man developed a generalized bullous eruption following topical treatment of actinic keratoses with fluorouracil. Indirect immunofluorescent studies of his serum and blister fluid revealed basement-membrane antibodies.
Bart BJ, Bean SF. Bullous Pemphigoid Following the Topical Use of Fluorouracil. Arch Dermatol. 1970;102(4):457–460. doi:10.1001/archderm.1970.04000100105022
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