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December 1970

Psoriasis and Systematized Epidermal Nevus

Author Affiliations

Osaka, Japan

From the Division of Dermatology, Osaka Kaisei Hospital (Dr. Sugai) and the Department of Dermatology, Osaka City University Medical School (Drs. Shimotoge and Saito), Osaka, Japan.

Arch Dermatol. 1970;102(6):656-660. doi:10.1001/archderm.1970.04000120074014

Multiple lesions of psoriasis circumscribed to those of systematized epidermal nevus occurred in a 31-year-old Japanese woman. She has had extensive verrucose or hyperkeratotic, brownish lesions on the distributional areas of cutaneous sensory nerves originated from the spinal cord C6-Th4 and L3-S1 over the right half of her body since birth. Psoriatic lesions first appeared on the brownish lesions at the age of 7 years. Microscopic sections of the psoriatic lesion revealed the same findings as lesions of ordinary psoriasis, losing the histologic features of epidermal nevus. A definite isomorphic response was evoked not only on lesions of epidermal nevus, but also on the apparently normal skin, following a skin abrasion, although most psoriatic lesions had disappeared with parenteral methotrexate therapy.

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