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December 1970


Arch Dermatol. 1970;102(6):694. doi:10.1001/archderm.1970.04000120112022

To the Editor.—  In regard to the report by Leavell and Yarbro of "Hydroxyurea: A New Treatment for Psoriasis" (Arch Derm 102:144-150, 1970), I was disappointed that they did not make specific reference to some of the studies of other cytotoxic agents in the treatment of psoriasis. Purine analogues,1-3 alkylating agents2,3 and other antimetabolites4 have been reported to be effective in psoriasis. Thus, the question is whether hydroxyurea has a better therapeutic index and less side effects in the treatment of psoriasis compared with these other cytotoxic drugs. A comparison study would be of interest. I share the feeling of the authors that there may be better, safer drugs than methotrexate in severe psoriasis.

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