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March 1971

Blood Levels of Methotrexate and the Treatment of Psoriasis

Author Affiliations

Miami, Fla

From the Dermatology Service, Veterans Administration Hospital, and the Department of Dermatology, University of Miami School of Medicine, Miami, Fla.

Arch Dermatol. 1971;103(3):243-249. doi:10.1001/archderm.1971.04000150013002

Methotrexate (Amethopterin [Britain]) is completely and rapidly absorbed in the usual therapeutic dosages. In order to maintain a blood level for approximately 36 hours, small oral doses should be given every eight hours or sooner. Twenty-three of 26 patients had good responses to a regimen of four such doses in a 24-hour period of each week.