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March 1971

Thymic Conversion of Candida albicans From Commensalism to Pathogenism

Author Affiliations

Austin, Tex

Arch Dermatol. 1971;103(3):311-319. doi:10.1001/archderm.1971.04000150081012

Generalized mucocutaneous candidiasis associated with thymoma and myasthenia gravis occurred in a 58-year-old woman. This is the third report of association of thymoma and candidiasis in cases without agammaglobulinemia, and the second reported case additionally associated with myopathy. Laboratory studies revealed primarily defective delayed hypersensitivity and one exception to otherwise normal humoral antibody responses. The lymphocytes were shown to be functionally normal in antigen recognition and processing, but the efferent phase of cellular immunity was defective. Nonspecific serum growth inhibition of Candida (transferrins) was normal. The causative interrelationship of mucocutaneous candidiasis, thymoma, and myasthenia gravis remains undetermined.

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